Ionic EquilibriumMedium
Question
The pKa of acetylsalicylic acid (aspirin) is 3.5. The pH of gastric juice in human stomach is about 2 to 3 and the pH in the small intestine is about 8. Aspirin will be
Options
A.Unionized in the small intestine as well as in the stomach.
B.Completely ionized in the small intestine as well as in the stomach.
C.Ionized in the stomach and almost unionized in the small intestine.
D.Ionized in the small intestine and almost unionized in the stomach.
Solution
HA $\rightleftharpoons$ H+ + A–
low PH ⇒ High [H+]
⇒ Equilibrium in backward direction
High PH ⇒ low [H+]
⇒ Equilibrium in forward direction
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