Principle of Inheritance and VariationMediumBloom L3
Question
Both sickle cell anaemia and Huntington's chorea are
Options
A.congenital disorders
B.pollulant-induced disorders
C.virus-related diseases
D.bacteria-related diseases
Solution
Sol.(a) [Key Concept: Genetic Disorders — Congenital] Both sickle cell anaemia and Huntington's chorea are CONGENITAL DISORDERS — genetic diseases present since birth (from conception), caused by inheriting mutant alleles. Sickle cell anaemia: autosomal recessive, caused by HbS mutation; RBCs become sickle-shaped, impairing oxygen transport. Huntington's disease: autosomal dominant, caused by CAG repeat expansion; progressive neurodegeneration. Both are hereditary, not caused by pathogens or pollutants.
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