Principle of Inheritance and VariationMediumBloom L3
Question
Chromosomal aberration occurs due to
1) deletion 2) duplication 3) inversion 4) translocation
Options
A.(1), (3) and (4)
B.(1), (2), (3) and (4)
C.(2), (3) and (4)
D.(1), (2) and (3)
Solution
Sol.(b) [Key Concept: Chromosomal Aberrations — Types] Chromosomal aberrations occur due to ALL FOUR: (1) Deletion — loss of a chromosomal segment (e.g., Cri-du-chat syndrome); (2) Duplication — repetition of a chromosomal segment; (3) Inversion — reversal of a chromosomal segment's orientation; (4) Translocation — transfer of a chromosomal segment to a non-homologous chromosome (e.g., Philadelphia chromosome in CML). All four are types of structural chromosomal aberrations. Answer: (1), (2), (3), and (4) = option (b).
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