Keeping in view the fluid mosaic model` for the structure of cell membrane, which one of thefollowin

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Keeping in view the fluid mosaic model` for the structure of cell membrane, which one of thefollowing statement is correct with respect to the movement of lipids and proteins from one lipid monolayer to the other (described as flip-flop)?

Accepted Answer

Singer and Nicolson (1972) suggested the widely accepted fiuid mosaaic of biological mem branes. According to this model the plasma membrane contains a bimolecular lipid layer both surfaces of which are interrupted by protein molecules. Some rotenins are attached at the polar surface of the lipid (, celled extrinsic protein) while, other (celled intrinsic proteins) either partially penetrate the bilayer or span the membrane entirely to stick out on both sides (called transmembrane proteins). Mobility of membrane protein due to fluid property of lipid bilayer was demonstrated by classical experiment of D Frye and M Edidin (1970). Lipid molecules very rarely migrate from one lipid monolayer to other monolayer of lipid bimolecular layer . Such a type of movement is called flip-flop or transbilayer movement and occurs once a month for any individual lipid molecule.

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