Principle of Inheritance and VariationMediumBloom L3
Question
Phenylketonuria, Huntington's disease and sickle cell anaemia are caused respectively due to disorders associated with
Options
A.chromosome 7, chromosome 11 and chromosome 12
B.chromosome 7, chromosome 12 and chromosome 11
C.chromosome 4, chromosome 7 and chromosome 11
D.chromosome 12, chromosome 4 and chromosome 11
Solution
Sol.(d) [Key Concept: Genetic Disorders — Chromosomal Locations] The correct chromosome locations: Phenylketonuria (PAH gene) = chromosome 12; Huntington's disease (HTT gene with CAG repeats) = chromosome 4; Sickle cell anaemia (HBB gene, beta-globin) = chromosome 11. So the correct answer is: chromosome 12 (PKU), chromosome 4 (HD), chromosome 11 (sickle cell) = option (d).
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