Principle of Inheritance and VariationEasyBloom L3
Question
Cri-du-chat syndrome in humans is caused by the
Options
A.loss of half of the short arm of chromosome 5
B.loss of half of the long arm of chromosome 5
C.trisomy of 21st chromosome
D.fertilization of an XX egg by a normal Y-bearing sperm
Solution
Sol.(a) [Key Concept: Cri-du-Chat Syndrome — Chromosome 5 Deletion] Cri-du-chat syndrome (French: 'cry of the cat') is caused by a partial DELETION of the SHORT ARM of chromosome 5. Affected children have abnormal facial expressions, mental retardation, a cat-like cry (due to laryngeal abnormalities), and heart defects. Trisomy of chromosome 21 causes Down's syndrome. Cri-du-chat is a chromosomal deletion disorder, not a trisomy.
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