Body Fluids and CirculationHard

Question

Sickle cell anaemia is due to

Options

A.change of amino acid in α -chain of haemoglobin
B.change of amino acid in β -chain of haemoglobin
C.change of amino acid in both α and β chain of haemoglobin
D.change of amino acid in either α or β -chain of haemoglobin

Solution

The sixth amino acid from the amino terminal end of β-chain of normal haemoglobin is glutamic acid while in sickle cell haemoglobin, it is valine.
This replacement results a change in confirmation of the haemoglobin molecule and the RBC becomes sickle - shaped.

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