Cell: The Unit of LifeMedium
Question
Match List I with List II :
| List I | List II | ||
|---|---|---|---|
| A. | Down's syndrome | I. | $11^{\text{th~}}$ chromosome |
| B. | $\alpha$-Thalassemia | II. | ' $X^{'}$ chromosome |
| C. | $\beta$-Thalassemia | III. | $21^{\text{st~}}$ chromosome |
| D. | Klinefelter's syndrome | IV. | $16^{\text{th~}}$ chromosome |
Choose the correct answer from the options given below :
Options
A.A-III, B-IV, C-I, D-II
B.A-IV, B-I, C-II, D-III
C.A-I, B-II, C-III, D-IV
D.A-II, B-III, C-IV, D-I
Solution
Sol. [Key Concept: Chromosomal basis of genetic disorders]
Down syndrome is associated with chromosome 21 trisomy (A–III). α-thalassaemia involves α-globin genes on chromosome 16 (B–IV). β-thalassaemia involves HBB on chromosome 11 (C–I). Klinefelter syndrome typically has an additional X chromosome, 47,XXY (D–II). Hence, option (1).
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