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Question

Inhibition of Succinic dehydrogenase enzyme by malonate is a classical example of:

Options

A.Competitive inhibition

B.Enzyme activation

C.Cofactor inhibition

D.Feedback inhibition

Solution

Sol. [Key Concept: Competitive enzyme inhibition]

Malonate resembles succinate and competes with it for the active site of succinate dehydrogenase. This is competitive inhibition; increasing substrate concentration can reduce the inhibitory effect. Hence, option (1).

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