Question
Arrange the following events occurring in Renin-Angiotensin mechanism in the correct order:
A. Increase in blood pressure and Glomerular filtration rate
B. Reabsorption of ${Na}^{+}$and water from distal parts of tubule due to Aldosterone
C. Fall in Glomerular filtration rate
D. Vasoconstriction by Angiotensin II and release of Aldosterone.
E. Renin converts Angiotensinogen into Angiotensin I, followed by Angiotensin II.
Choose the correct answer from the options given below:
Options
Solution
Sol. [Key Concept: Sequence of the renin–angiotensin mechanism]
The JGA plays a complex regulatory role
- A fall in glomerular blood flow/GFR can activate the JG cells to release renin which converts angiotensinogen in blood to angiotensin I and further to angiotensin II
- Angiotensin II, being a powerful vasoconstrictor, increases the glomerular blood pressure and thereby GFR.
- Angiotensin II activates the adrenal cortex to release aldosterone.
- Aldosterone causes reabsorption of ${Na}^{+}$and $H_{2}O$ from the distal parts of the tubule. This leads to an increase in blood pressure and GFR.
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