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Question

Which of the following statements are correct with reference to packaging of DNA helix?

A. Histones are organized to form a unit of eight molecules called histone octamer.

B. Histones are negatively charged basic proteins.

C. Histones are rich in the basic amino acid residues - lysine and arginine.

D. The positively charged DNA is wrapped around the histone octamer to form nucleosome.

E. The packaging of chromatin at higher levels requires an additional set of proteins called non-histone chromosomal proteins.

Choose the correct answer from the options given below:

Options

A.A, C and E only
B.B, D and E only
C.C, D and E only
D.A, B and D only

Solution

Sol. [Key Concept: DNA packaging — nucleosomes and histone proteins]

Sol. Eight Histones are combined to form a histone octamer. Histones are positively charged basic proteins that are rich in basic amino acids (lysine and arginine). The negatively charged DNA is wrapped around the histone octamer to form nucleosome. The packaging of chromatin at higher levels requires NHC (non histone chromosomal) proteins.

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