Principle of Inheritance and VariationMediumBloom L3
Question
Match Column I with Column II
| Column I | Column II |
| A. Sickle-cell anaemia | 1. 7th chromosome |
| B. Phenylketonuria | 2. 4th chromosome |
| C. Cystic fibrosis | 3. 11th chromosome |
| D. Huntington's disease | 4. X-chromosome |
| E. Colour blindness | 5. 12th chromosome |
Options
A.A→2; B→1; C→4; D→3; E→5
B.A→5; B→1; C→2; D→3; E→4
C.A→4; B→2; C→1; D→3; E→5
D.A→3; B→5; C→1; D→2; E→4
Solution
Sol.(d) [Key Concept: Genetic Disorders — Chromosome Locations] Correct matches: A (Sickle-cell anaemia) → 3 (11th chromosome — HBB gene); B (Phenylketonuria) → 5 (12th chromosome — PAH gene); C (Cystic fibrosis) → 1 (7th chromosome — CFTR gene); D (Huntington's disease) → 2 (4th chromosome — HTT gene with CAG repeats); E (Colour blindness) → 4 (X-chromosome — opsin genes). Answer: A→3, B→5, C→1, D→2, E→4 = option (d).
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