Principle of Inheritance and VariationMediumBloom L3

Question

Given pedigree shows that the trait is inherited as autosomal dominant. Trace the genotype of Mother and Father

Options

A.Father AA, Mother aa
B.Father AA, Mother Aa
C.Father aa, Mother AA
D.Father aa, Mother Aa

Solution

Sol.(d) [Key Concept: Autosomal Dominant — Pedigree Genotype Analysis] From the pedigree showing autosomal dominant inheritance: The trait is autosomal dominant (shown by filled symbols = affected). Father is UNAFFECTED (empty square) → Father must be aa (homozygous recessive, no dominant allele). Mother is AFFECTED → Mother carries at least one A allele. Since some children are unaffected (aa), the mother must be HETEROZYGOUS (Aa), contributing either A or a to offspring. An AA mother would produce all affected children. Therefore: Father = aa, Mother = Aa → option (d).

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