Principle of Inheritance and VariationMediumBloom L1
Question
The incorrect statement with regard to Haemophilia is:
Options
A.It is a recessive disease
B.It is a dominant disease
C.A single protein involved in the clotting of blood is affected
D.It is a sex-linked disease
Solution
Sol.(b) [Key Concept: Haemophilia — Incorrect Statement] The incorrect statement is (b): Haemophilia is NOT a dominant disease — it is an X-LINKED RECESSIVE disease. Affected individuals must be hemizygous (males: X^h Y) or homozygous (females: X^h X^h). Carrier females (X^H X^h) are phenotypically normal. The CORRECT statements are: (a) it IS recessive; (c) a single protein (Factor VIII in Haemophilia A or Factor IX in B) in the clotting cascade is affected; (d) it IS sex-linked (X-linked).
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