Principle of Inheritance and VariationMediumBloom L3

Question

The ratio of 2 : 1 is observed in case of

Options

A.suppressor gene
B.dominant-recessive epistasis
C.complementary gene
D.lethal gene

Solution

Sol.(d) [Key Concept: Lethal Gene — 2:1 Ratio] A 2:1 phenotypic ratio in F2 is observed in case of LETHAL GENES. When the homozygous dominant condition (AA) is lethal (causes embryonic death), the expected 1:2:1 genotypic ratio becomes 1AA(dead):2Aa:1aa → only Aa and aa survive = 2:1 ratio among live offspring. Classic example: yellow coat colour in mice (AY allele — AY AY is lethal; AY a = yellow coat; aa = black coat → ratio 2 yellow:1 black among live mice).

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