Body Fluids and CirculationHard
Question
Which of the following substances, if introduce in the blood stream, would cause coagulation, at the site of its introduction ?
Options
A.Fibrinogen
B.Prothrombin
C.heparin
D.Thromboplastin
Solution
Lipoproteinaceous, thromboplastin is released by the injured tissue. This reacts eith Ca2+ ions present in blood and foems a proteinaceous enzyme called prothrombinase. Later in the presence of Ca2+ inactivates heparin (anticoagulant) and catalyses prothrombin (inactive plasma protein) into an active thrombin protein. Thrombin acts an enzyme and catalyses fibrinogen (a soluble plasma protein) into an insoluble gibre like polymer, fibrin. These fibres form a dense network upon the wound and trap blood corpuscles (WBCs, RBCs and platelets) and thjus form a clot. This clot seals the wound and stop bleeding. In blood vessels, thromboplastin do not release due to which blood does not clot. But external thromboplastin to blood will cause blood clotting at the site of its introduce due to formation of prothrombinase.
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