Principle of Inheritance and VariationHard

Question

Whose experiments cracked the DNA and discovered unequivocally that a gentic code is a triplet ?

Options

A.Nirenberg and Mathaei
B.Hershey and Chase
C.Moegan and Sturtevant
D.Beadle and Tatum

Solution

The experimen of triplet code was simply an assumption till 1961, when Nirenberg and Mathaei prove its existence by experiments. They were able to synthesize artificial mRNA which contained only one nitrogenous base, ie, uracil. This synthetic poly U srquence was then placed in a cell free system containing protein synthesizing enzymes (extracted from bacterium E. coli) and 20 amino acids togethel with necessary ATP. During the process, a small polypeptide molecule was produced, which was formed by the linking of phenylalanine. This suggested that UUU is tha code for phenyl alanine. Nirenberg got Nobel Prize for his contributions.

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