Principle of Inheritance and VariationHard
Question
Haemophilia is more commonly seen in human males than in human frnan females because
Options
A.this disease is due to an X-linked dominant mutation
B.a greater proportion of girls die in infancy this disease is due to an
C.this disease is due to an X-linked recessive mutation
D.this disease is due to a Y-linked recessive mutation
Solution
Haemophilia a hereditary (recessive X-linked) disease iscaused due to fault in genes which controlling the factor VIII and IX, located on X-chromosome. Themale carris only one X- chromosome, other sex chromosome carries no genes for blood clotting, so the condition is usually seen only in males where only one faulty chromosome is needed.
While a female with one faulty X-chror osome will be carrier. So, in Females two faulty X- chromosome are needed to cause the disease.
While a female with one faulty X-chror osome will be carrier. So, in Females two faulty X- chromosome are needed to cause the disease.
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