Excretory Products and their EliminationHard

Question

The principle nitrogenuous excretoryin humans synthesised

Options

A.in kidneys but eliminated mostly through liver
B.in kidneys as well as eliminated by kidneys
C.in liver and also eliminated by the same through bole
D.in the liver, but eliminated mostly through kidneys

Solution

In humans, the pronciple nitrogenous excretory compound (ie, urea) is synthesis in liver by ornithine cycle. In liver, one molecule of CO2 is activated by biotin and combines with two molecules of NH3 in the presense of carbamyl phosphate synthesis enzyme and 2ATP to form cabamy phos[hate and one molecule of H2O is released. Carbamyl phosphate reacts with ornithine and forms citrulline. Citrulline combines with another molecule of ammonia and form arginine that is broken into urea and ornithine in the presence of an enzyme arginase and water.
      2NH3 + CO2 NH2 - CO - NH2 + H2O
urea is eliminated mostly through kidney as nitrogenous excretory product.

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